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Harmonizing Timeless Wisdom with Contemporary Fitness

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Everyone in the world of fitness seems to want the bright new shiny object. And while it’s true that we’ve made a lot of progress in the world of exercise science over the last 20 years (to say nothing of the last 50), it’s also true that the old-school guys for sure knew what they were talking about.


Think about it: Men in the 1950s like Reg Park and Steve Reeves were able to build absolutely insane physiques without the benefit of anabolic steroids. A number of early “odd lift” competitors (the forerunner to modern powerlifting) set records that stood for decades or have never been beaten. What’s more, modern exercise science stands on the shoulders of these giants. 

So don’t throw out the baby with the bathwater, going on a totally old-school approach. Instead, think about what the “ancients” knew that has largely been forgotten and how you can synergize it with what we now know about the world of strength training and fitness. Then combine the best of both worlds for increased benefits overall. 

Embracing Vintage Fitness Wisdom

The greats of the bygone era loved functional movement training. In fact, most of what was done for “cardio” was largely what the kettlebell crew would do these days, albeit with dumbbells rather than kettlebells. Think snatches and cleans for super high reps. And while we’re on the subject of kettlebells, let’s not forget that there are few things more old school than the kettlebell itself, which dates back centuries in Russia. 

Similarly, the greats of yesteryear loved “bread and butter” movements like deadlifts, squats, and overhead pressing. These are some of the most “functional” movements you can do with a barbell in as much as they carry over to your daily life. Few things are more “functional” than picking something up off the ground, raising it over your head, or standing up under load. 

Likewise, bodyweight movements can be extremely helpful in overcoming plateaus and were favorites of the “old school” school guys. You can never do too many chin-ups and while your shoulders might object to too many dips, the chest dip was known as “the upper body squat” back in the day for a reason. Planks and pushups likewise are great for breaking plateaus and maintaining fitness. 

Finally, consider how the greats of old dieted. They weren’t swayed by fad diets. They believed in generous consumption of healthy, whole foods, with an eye toward connection with the body to know when you were actually hungry and when you were eating out of boredom. Choosing whole, nutrient-dense foods will never lead you astray. 

Much of what we’ve just talked about is the essence of “everything old is new again.” The Silver Age of Bodybuilding is coming back into fashion among natural lifters precisely because it aligns so well with everything that we currently know about modern strength training, holistic wellness, and dieting. So don’t be impressed with the new shiny thing just because it’s new and shiny. Try and pull from the greats of old and update what they did with the newest information in exercise science. 

That’s how you get the best of both worlds. 

What do we know now that they didn’t know back in the day? What did the old-school guys know that we’ve forgotten? Leave your thoughts in the comments below.

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Fitness

A New Generation of Weight-Loss Drugs Target Brain Plasticity

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A breakthrough in weight-loss drug development is on the horizon, thanks to the innovative research led by Associate Professor Christoffer Clemmensen from the Novo Nordisk Foundation Center for Basic Metabolic Research at the University of Copenhagen. Clemmensen and his team have developed a new type of weight-loss drug that affects brain plasticity and shows promising results in preclinical studies. Published in the scientific journal Nature, this new drug could potentially offer a more effective and targeted approach to weight loss.

The Role of GLP-1 in Weight Loss

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In their study, the researchers demonstrate a novel use of the weight-loss hormone GLP-1. Traditionally, GLP-1 has been used to help manage weight, but Clemmensen’s team discovered that it could serve as a ‘Trojan Horse’ to deliver specific molecules into the brain. These molecules target the brain’s plasticity, resulting in significant weight loss in mice.

The study suggests future patients could achieve similar weight-loss results with lower doses, potentially reducing side effects.

From Mice to Humans: The Next Steps

Currently, the new drug is in the preclinical phase, involving studies on cells and experimental animals. The next critical step is to conduct clinical trials with human participants. These trials will determine how the drug works in humans and whether the impressive results seen in mice can be replicated.

Clemmensen is optimistic about the potential of this drug, noting that GLP-1-based drugs are already known to induce weight loss. By attaching a molecule that affects the glutamatergic neurotransmitter system to GLP-1, the team has created a drug that may offer significant weight loss benefits. Previous studies with similar compounds have shown promise in human participants, further supporting the potential of this new drug.

Overcoming the Brain’s Defense Mechanisms

The human body is naturally designed to defend a certain body weight and fat mass, a trait that has historically helped humans survive periods of food scarcity. However, in today’s world, where obesity is a growing problem, this evolutionary advantage can be detrimental.

Clemmensen and his team developed an interest in molecules used to treat chronic depression and Alzheimer’s disease, which block a receptor protein called the NMDA receptor. These receptors play a key role in brain plasticity, affecting long-term changes in brain connections. By targeting these receptors, the new drug can potentially alter the brain’s structure and function to promote weight loss.

The Potential of Targeted Drug Delivery

A significant innovation of this new drug is its targeted delivery method. By combining GLP-1 with molecules that block the NMDA receptor, the drug specifically targets the neurons that control appetite. This specificity reduces the risk of non-specific effects that can cause severe side effects, a common issue with many neurobiological drugs.

“This family of molecules can have a permanent effect on the brain,” Clemmensen explains. “We see molecular signatures of neuroplasticity in our work, but in this case, in the context of weight loss.” The drug’s ability to cross the blood-brain barrier and target specific brain regions marks a significant advancement in weight-loss treatment.

Implications for Future Treatments

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The implications of this research extend beyond weight loss. By using GLP-1 as a vehicle to deliver drugs to specific parts of the brain, Clemmensen’s team has opened the door to a new class of treatments for various neurodegenerative diseases and psychiatric disorders. This approach could lead to more effective and targeted therapies for conditions that have been difficult to treat due to the challenges of crossing the blood-brain barrier.

Understanding Neuroplasticity

Neuroplasticity, or the brain’s ability to restructure itself by forming new neural connections, is central to this new drug’s mechanism. This ability allows the brain to adjust to new experiences, learn new skills, and recover from injuries. By harnessing neuroplasticity, the new drug can potentially bring about long-lasting changes in brain function that promote weight loss.

In conclusion, the development of this new weight-loss drug represents a significant step forward in the fight against obesity. By targeting brain plasticity and utilizing innovative drug delivery methods, Clemmensen and his team have created a promising new treatment that could benefit millions of people struggling with weight management. As research progresses and clinical trials begin, the potential for this drug to revolutionize weight-loss therapy becomes increasingly clear.

Are you excited about the brain side effects of weight loss drugs? Leave your thoughts in the comments below. 

 

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Stay Pain Free With These Simple Stretches

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When it comes to staying pain-free, sometimes it’s a joint effort between you and your physical trainer. However, if you don’t have a trainer, here are simple stretching tips to prevent hip, back, and ankle pain. In this article, we’ll explore these tips and how they can help you stay mobile and pain-free. 

Mobility is simply how well your joints move. Someone who has strong mobility will be strong within different ranges of motion. It’s important to train mobility before engaging in exercises like weightlifting and even walking.

Walking involves a lot from the body: foot plantar flexion, ankle dorsiflexion, hip flexion and extension, rotation in the pelvis, and stability in the core. Doing mobility exercises before a walk is important to prime the body for all these functions. By enhancing mobility, you can improve your performance and reduce the risk of injuries.

Mobility Exercises

Centenari shared two effective mobility exercises that can be done before a walk to prevent pain and improve joint function.

The CAR Ankle Exercise

CAR stands for controlled articular rotations. This exercise involves taking the joint through its full range of motion, and exploring how well you can control these outer ranges. This helps uncover where you may be limited or where progress can be made, both neurologically and kinesthetically.

How to Perform the CAR Ankle Exercise

 

  1. Sit on the floor and raise your right leg off the ground.
  2. Pull your right leg to your chest by using both hands to hold up your knee, keeping your leg suspended in the air.
  3. Create small circles with your foot by pointing your toe and rotating your ankle.
  4. Perform the rotation in one direction for 30 seconds, then switch directions for another 30 seconds.
  5. Repeat the exercise with the other leg.
  6. Practice the exercise for 90 seconds on each side.

This exercise helps improve the range of motion and strength in your ankles, which is essential for walking and other physical activities.

The 90-90 Exercise

The 90-90 exercise is a floor-based position that focuses on hip internal and external rotation. It not only helps increase the range of motion and functionality in the hips but also addresses low back issues that often stem from hip dysfunction.

How to Perform the 90-90 Exercise

  1. Sit on the floor with your right leg bent in front of you at a 90-degree angle.
  2. Position your left leg behind you, also bent at a 90-degree angle.
  3. Sit up straight, take a deep breath, and slowly stretch yourself over your right knee.
  4. Hold the stretch for one second before sitting up again.
  5. Do it again for 90 seconds, then switch to the other side.
  6. Perform the same stretch on the left side.

This exercise helps improve hip mobility and can alleviate lower back pain by addressing hip dysfunction.

Incorporating these simple mobility exercises into your routine can help you stay pain-free and improve your overall joint function. Whether you’re an athlete or just someone looking to stay active, maintaining good mobility is key to preventing injuries and enhancing performance. Remember to consult with your doctor or a physical trainer to ensure these exercises are appropriate for your needs and abilities. Stay active, stay mobile, and stay pain-free!

Will you be using these mobility exercises? Leave your thoughts in the comments below.

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Exercises Enhances Effectiveness of Cancer Treatments in Seniors

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New research suggests that exercise could make certain cancer treatments more effective. Specifically, a study has shown that moderate-to-vigorous exercise can help improve antibody therapies used to treat chronic lymphocytic leukemia (CLL). This form of leukemia affects the white blood cells and is common among older adults. In this article, we’ll explain how exercise can potentially boost cancer treatment and what this means for seniors battling this disease.

Researchers at the Universities of Birmingham and Bath conducted a study involving 20 people aged between 45 and 82 who were diagnosed with CLL but had not yet started treatment. These participants were asked to engage in a 30-minute session of moderate-to-vigorous cycling. Blood samples were taken before, immediately after, and an hour after the exercise session.

The researchers found that exercise increased the number of natural killer cells in the blood by 254%. Natural killer cells are a type of immune cell that can target and kill cancer cells. This increase is significant because natural killer cells play a crucial role in fighting cancer.

How Exercise Helps

Immediately after exercise, the researchers noted a 67% increase in the number of cancer cells in the blood samples compared to the samples taken before exercise. This might seem alarming, but it actually means that the exercise helped move the cancer cells out of hiding in the body and into the bloodstream, where they can be more easily targeted by treatments.

The study focused on an antibody therapy called Rituximab, commonly used to treat CLL. Rituximab works by attaching to a specific protein on the surface of cancer cells, making them easier for natural killer cells to recognize and attack.

The researchers tested the blood samples with and without Rituximab. They found that the natural killer cells were twice as effective at killing cancer cells when Rituximab was present, especially in the samples taken immediately after exercise. This suggests that exercise can enhance the effectiveness of antibody therapy by making cancer cells more vulnerable to attack.

Potential Benefits for Seniors

These findings are particularly relevant for seniors undergoing treatment for CLL. The potential for exercise to improve the efficacy of antibody therapies like Rituximab could offer new hope for better treatment outcomes. Moreover, the study suggests that exercise might help in monitoring patients after they have completed treatment. By increasing the number of detectable cancer cells in the blood, exercise could make it easier to spot any remaining or returning cancer cells.

Dr. James Turner from the University of Birmingham highlighted the potential benefits of this research, stating that it could open up new avenues for improving cancer treatments. However, he also emphasized the need for further studies to confirm these findings in larger groups of patients undergoing treatment.

Dr. John Campbell from the University of Bath added that exercise seems to help move cancer cells into the bloodstream, where they are more susceptible to treatment. This could be particularly useful for patients in the monitoring phase after treatment.

The Importance of Personalized Exercise Plans

While the results are promising, it is crucial for seniors to discuss any new exercise routines with their doctors. Caroline Geraghty, a Senior Specialist Information Nurse at Cancer Research UK, advises cancer patients to seek medical advice before starting any exercise program. Each person’s needs and abilities are different, and it’s important to find the right type of exercise that is both safe and beneficial.

This research adds to the growing body of evidence that exercise can play a valuable role in cancer treatment. For seniors with CLL, incorporating moderate-to-vigorous exercise into their routine could potentially enhance the effectiveness of their treatments and improve their overall health. As always, consult with healthcare providers to create a personalized exercise plan that suits your needs and abilities.

Exercise is known to improve physical and mental well-being, and now, it may also be a powerful ally in the fight against cancer. As research continues, we hope to see more concrete recommendations on how to best incorporate exercise into cancer treatment plans. For now, staying active within your capabilities and under medical guidance remains a beneficial approach for overall health and well-being.

What do you think of the findings of these studies? Leave your thoughts in the comments below.

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